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Using AEGIS: Increasing Aptamer Diversity

The dP and dZ bases increase the chemical repertoire of nuleic acids for aptamer selections .  Of special note is the NO2 group present on dZ.

The figure below shows one application of AEGIS for the selection of aptamers specific to a cell surface protein on a cancer cell.




Biondi et al., 2016; Sefah et al., 2014; Zhang et al., 2015, 2016